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Shenzhen, China – Durastab has successfully commissioned ton-scale production equipment for its ProCide™ 300 Preservative, marking a significant milestone in enhancing production capacity and ensuring a stable supply for the in vitrodiagnostics (IVD) industry. This advancement supports the company's commitment to import substitution and providing high-quality, cost-effective raw materials.
ProCide™ 300 is a water-soluble antimicrobial formulation widely used to extend the shelf life of reagents. It contains 3% active ingredients—a combination of 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-Methyl-4-isothiazolin-3-one (MIT)—dissolved in a proprietary polyol stabilizer system containing alkyl carboxylate. It is effective within a recommended pH range of 2.5 to 8.5 and is suitable for preparing various buffers, such as ELISA buffers, sample/substrate dilution buffers, and other solutions used in immunoassays and biochemical diagnostics.
The preservative's formula acts on multiple specific target sites within microbial metabolism, preventing the development of high-level microbial resistance and ensuring long-term effectiveness for IVD components during storage. By attacking key enzymes in the Krebs cycle (including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and NADH dehydrogenase), ProCide™ 300 rapidly inhibits broad-spectrum microbial activity. Its efficacy surpasses that of traditional preservatives like thimerosal and sodium azide.
Committed to developing import-substituting products, Durastab utilizes high-quality raw materials to produce ProCide™ 300, which has gained recognition from major reagent manufacturers and helps customers reduce costs by up to 70%. The recent successful validation of a 2,000L reactor for producing two-ton batches guarantees a stable and scalable supply of ProCide™ 300, providing critical production assurance for market demands.
The ProCide™ series of liquid preservatives is renowned for its safety, eco-friendliness, and stability, effectively inhibiting bacteria and fungi to extend the shelf life of IVD reagents . At low working concentrations, it offers broad-spectrum protection while minimizing health hazards, toxicological concerns, and disposal issues compared to conventional alternatives .
Among the ProCide™ series, ProCide™ 300 remains the most popular formulation due to its magnesium salt-free composition and three-year shelf life. For applications requiring stability under extreme pH or temperature conditions, ProCide™ 950 is the recommended choice.
This ton-level production capability solidifies Durastab's position as a reliable supplier of critical raw materials for the global IVD industry.
